Company Profile
Gene Sincere Biotechnology Co Ltd (Gene Sincere) was established in 2017 focusing on R&D and commercialization of biotechnological products and processes in Hong Kong, RRC and overseas. Since its establishment, Gene Sincere has developed rapidly and achieved impressive performance.
Research Background
The core technologies in producing authentic EGF and bFGF, of which a number of international patents have been obtained for their protection, have been developed by Professor Wong Wan Keung and his team in the past 3 decades. Professor Wong received his PhD from UBC in Vancouver, Canada, and then worked as a Research Scientist at a leading biotechnology, Allelix Inc. in Toronto, Canada. He has been affiliated as as a professor with the Hong Kong University of Science and Technology since 1990. In addition to the patents obtained for his inventions, Professor Wong has also won many awards in different parts of the world.
After more than 30 years of endeavour, Professor Wong’s team has developed proprietary technologies to efficiently produce two recombinant skin growth factors: epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF). Their efforts paid off and they became the first group worldwide capable of producing authentic EGF and bFGF, which share the same structures with their human counterparts. The benefits of employing the two authentic factors as active ingredients in skin care products include: high levels of important properties including safety, biological activity and stability. Another noteworthy point is that Gene Sincere have the proprietary rights for producing of the two recombinant skin growth factors.
Research Team
Professor Wong Wan Keung Chief Technical Director
Professor Wong obtained his PhD in Microbiology from UBC in 1986. Not only is Professor Wong specialized in microbiology, but he also excels in molecular biology, immunochemistry and fermentation technology. Moreover, he has more than 30 years of experience in the development and commercial applications of varies biotechnological aspects.
Through advanced recombinant DNA technology and streamlined purification processes, Professor Wong’s group has remarkably pioneered the production of authentic as well as high quality EGF and bFGF, thus facilitating their application to cost-effective skin and medical care industries. The team’s achievements have helped laid the foundation for further biotechnological discoveries and developments for skin care and cosmetic applications.
Authority certification
Wong, W.K.R. (2020)
Wong, W.K.R., Ng, K.L. (2020) Means and method for enhancing growth of fish. Japanese patent No.: 6707441; Granted on May 22, 2020.
Wong, W.K.R. (2020) Means and method for expression of authentic human epidermal growth factor and/or basic fibroblast growth factor in cytoplasm and/or Culture Medium of Escherichia coli. Chinese Patent No. CN 105143451 B; Granted on 14 February 2020.
Wong, W.K.R. (2019)
Wong, W.K.R.,Hu, X.H., Ng, K.L. and Lam, C.C. (2019) Methods and means for expression of authentic and bioactive basic fibroblast growth factor in Bacillus subtilis. Hong Kong Short-term Patent No. HK1255118; Granted on 2 Aug 2019.
Wong, W.K.R., Kwong, W. Y. (2019) Improved means and method for hyper-production of authentic human basic fibroblast growth factor in Escherichia coli. US Patent No. 10,273,520; Granted on April 30, 2019
Wong, W.K.R. (2018)
Wong, W.K.R., Hu, X.H., Ng, K.L. and Lam, C.C. (2018) Methods and means for expression of authentic and bioactive basic fibroblast growth factor in Bacillus subtilis. USA, China and Japan (under application).
Wong, W.K.R. (2018) Means and method for expression of authentic human epidermal growth factor and/or basic fibroblast growth factor in cytoplasm and/or culture medium of Escherichia coli Japan Patent No.6404901. Granted on 21 Sept 2018.
Wong, W.K.R. (2017)
Wong, W.K.R., Kwong, W. Y. (2017) Improved means and method for hyper-production of authentic human basic fibroblast growth factor in Escherichia coli. Hong Kong short-term patent No. HK1228651; Granted on November 3, 2017.
Wong, W.K.R. (2017) Means and method for expression of authentic human epidermal growth factor and/or basic fibroblast growth factor in cytoplasm and/or culture medium of Escherichia coli Hong Kong short-term patent No. HK1219200; Granted on March 24, 2017.
Wong, W.K.R. (2017) Means and method for expression of authentic human epidermal growth factor and/or basic fibroblast growth factor in cytoplasm and/or culture medium of Escherichia coli US Patent No. 9,580,484 B2; Granted on February 28, 2017.
Wong, W.K.R., Ng, K. L. (2017) Means and method for enhancing growth of fish. Hong Kong short-term patent No.: HK1218486; Granted on February 17, 2017.
Wong, W.K.R. (2015)
Wong, W.K.R. (2015) Means and methods for producing authentic human basic fibroblast growth factor. US Patent: 9,017,968 B2; Granted on 28 April 2015.
Wong, W.K.R. (2014)
Wong, W.K.R., Lam, K.H.E. and Tsang, M.W. (2014) Method and composition for treating skin wounds with epidermal growth factor. German Patent 60346186.7; Granted on 18 Jun 2014.
Wong, W.K.R., Lam, K.H.E. and Tsang, M.W. (2014) Method and composition for treating skin wounds with epidermal growth factor. PCT European Patent EP1482966B1; Granted on 14 May 2014.
Wong, W.K.R., Lam, K.H.E. and Tsang, M.W. (2014) Method and composition for treating skin wounds with epidermal growth factor. United Kingdom Patent EP1482966; Granted on 14 May 2014.
Wong, W.K.R., Lam, K.H.E. and Tsang, M.W. (2014) Method and composition for treating skin wounds with epidermal growth factor. French Patent EP1482966; Granted on 14 May 2014.
Wong, W.K.R., Lam, K.H.E. and Tsang, M.W. (2014) Method and composition for treating skin wounds with epidermal growth factor. Hong Kong Patent HK1071525; Granted on 20 May 2014.
Wong, W.K.R. (2011)
Wong, W.K.R., Lam, K.H.E. and Tsang, M.W. (2011) Method and composition for treating skin wounds with epidermal growth factor. Taiwan PCT National Phase Patent, Taiwanese Patent No.: I 348912. Granted on 11 Sep 2011
Wong, W.K.R. (2009)
Wong, W.K.R., Lam, K.H.E. and Tsang, M.W. (2009) Method and composition for treating skin wounds with epidermal growth factor. China PCT National Phase Patent, Chinese Patent No. 3. Granted on 23 Dec 2009
Wong, W.K.R., Lam, K.H.E. and Tsang, M.W. (2009) Method and composition for treating skin wounds with epidermal growth factor. United States PCT National Phase Patent, US Patent No. 7,517,528 B2. Granted on 14 Apr 2009
Awards and honors
Year 2020
Industry Advisor, “Certificate of Appointment” by Social Enterprise Research Academy
Year 2018
Asian Chinese Leader, to be awarded by Asian College of Knowledge Management, 21 July 2018, Hong Kong
Fellowship, awarded by Social Enterprise Research Academy, 5 May 2018, Hong Kong
Year 2017
Invited as a keynote speaker in the “International Conference on Genetics & Molecular Research”, May 22-24, 2017 at Dubai, UAE.
Year 2016
Golden Medical Award, awarded by Global Medical Discovery. Canada
The Manager of the year and the Best Enterprises in the field of biotechnology, awarded by Europe Business Assembly
Year 2015
“Certificate of Recognition” presented by the “International Conference on Targeting Diabetes and Novel Therapeutics” held on September 14-16 in Las Vegas, Nevada, USA
Year 2014
Higher Education Outstanding Scientific Research Output Award, Nominated by HKUST
The world’s 80 outstanding Chinese entrepreneurs, management strategy and humanistic philosophy, Chinese business leader, awarded by China Daily.
Year 2013
Honored by Wen Wei Po 15 March 2013
Year 2012
Named as one of the “ Chinese patriotic talents “and a 4 page introduction was published in < Chinese patriotic national code > 2012
Year 2011
Most Promising Entrepreneurship Award Winner of the prestigious Asia Pacific Entrepreneurship Awards, Hong Kong
Long Service Award, awarded by HKUST
Year 2008
2008 Hong Kong Awards for Industries: Technological Achievement Certificate of Merit. Hong Kong Science & Technology Parks
Certificate of honor
